yes we've had both: A 31ft Cougar (for 10 years) pulled behind an F-250 and then an F-350:
Now the 25ft Axis + Wife's car:
We went from a 27 ft travel trailer to the 5er.
It was a huge step going from the travel trailer to the 5er: 5er pulled much nicer, trucks didn't bother us at all, more room, etc. (also more $$). We liked the 5er but it really is a lot of work to setup.
Now with the Axis & Car: We have the option of not taking the car if we don't want to (don't have that option with the 5er). Even with pulling the car on a dolly it is much easier to setup the Axis (if you don't need the car you just park). (Granted if the 5er had some of the niceties of the Axis like the power awning it would have been a smidge easier to setup as well).
The biggest difference is that the 5er + truck was a lot going down the road and you really knew it was back there (don't think the wife took the wheel more than once in all the 10 years of having the 5er--so far the wife has driven on every long trip we've taken with the Axis; even the ones where we towed her car).
The total cost of the motorhome + car is also higher than the 5er + pickup (which is to be expected since we now have 3 engines to take care of instead of 1).
One of the biggest differences: With the motorhome you're not cooped up inside a tiny cab for the 6-8 hours you are driving (someone can be watching TV, using a computer or tablet, playing video games, etc.).
There have been a few days these past two winters, though, that I've really missed the F-350 4x4!