We took 16 from Cody to Buffalo on our way to the Black Hills. I was driving a 2013 RAM 2500 diesel and internal exhaust brake pulling a 27' TT, but no problem. It is a pretty steep and winding road, but as others have said, take your time. It's definitely worth taking it slow, and take some pictures. It is one of the Scenic Byways for a reason.
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