Same wisdom as for any vehicle... make sure your tire pressure is correct, keep the engine tuned up, keep your speed reasonable, avoid jackrabbit starts, and so on.
I'm using a Garmin EcoRouteHD which reads the fuel flow data from the engine's OBDC port. From that data, we're averaging just about 10MPG with our 28Z (which is actually 29ft-10") on a E450 chassis.
One thing with the EcoRoute - I can watch how varying the speed by a few MPH affects the fuel mileage.
I usually drive between 55~60mph on the interstate, and I get passed by many other RV'ers - especially those towing 5th wheels - can't imagine they are saving much gas at 70MPH.
I used to have a fuel flow metering system on my boat - which was so depressing it was best not looked at (I averaged 0.7~0.8MPG in the boat).
The only other thing I can think of - which I might do next year - is to install a set of air-tabs (
Airtab: Aerodynamic fuel savers for truck, tractor, trailer, bus, RV). They claim to increase mileage by 2~5%. Whether or not it is worth the $220 to save 5% in fuel is debatable; I put 2,500 miles on my RV so far this summer - so it would have saved $50, if I got a 5% fuel reduction.
However, the air-tabs are said to help the stability of the rig, especially when being passed by semis etc., and if that is a side benefit, it might be worth the investment.