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Going in the Northern direction I don't think you'll have that many issues, I-75 pretty much all the way (go around Atlanta and Chattanooga if you don't like the traffic). Along that route I think the steepest freeway is I-75 just south of Cincy at the OH KY border, but going North that is downhill.
When you're in Toledo pick up US-23 (there are exit signs for it on I-75) and take that--it will take you straight into Ann Arbor (and avoid the I-75 mess in Southern Michigan). (There are usually fewer trucks on US-23 than I-75 as well.)
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