IMHO it depends on a lot of things. Time of year, your available time, your tolerance to finding full campgrounds, your destination, and probably others too.
We didn't like being tied to a fixed schedule. We would learn of places we would like to visit en route and change our schedule accordingly, something you can't do if you if you pre-schedule everything. Occasionally the campground we had planned to stay at was full and we had to move on to a second choice. Usually the person at the first choice CG would recommend another CG. If all else fails there is always a Walmart.
Of course, if you are planning to attend a certain event, you had better have reservations at the event.
Hope this helps.
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