I went for well over 10 years without a tire problem on the road, and then had to replace two tires with the spares within the last few months.
The first was on small rental car that had aluminum rims, making the tire very light. To help matters it only had 5 lugs per wheel which came off relatively easy. I could have called, but being in a hurry replaced it myself in less than 30 minutes (took a while to find all parts and jacking instructions on car I wasn't familiar with).
A little over two months ago I blew tire on my camping van on I-95 in Florida, and replaced it while parked on shoulder. These wheels/tires are slightly larger and heavier than what's on Axis/Vegas, or Ford Class Cs, but I managed to get back on road in about 30 minutes (wasn't timing, but expect we'll under an hour).
Comparing the two, there wasn't really that much difference in total time or effort even though my van's tires are at least twice as heavy, use 8 lugs, and are tighten to 140 lb-ft.
Getting everything set up takes a lot of time regardless of vehicle size. Granted, I had to jack up more weight, but the much heavier van wasn't that different because jack goes under axle, so no energy wasted with car's spring.
Replacing a front tire on an Axis/Vegas or Ford Class C should take similar effort. Rear dually tires should be a little harder, but I expect I'd be back on road in less than an hour. I'd definitely want a spare on smaller rigs.
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