I just added Eez Tire TPMS to my Axis (E450 with 16 inch ford rims). No issues (yet) but I removed the anti theft covers which made mine much smaller (lighter) so the front they fit with no extention. The OEM had a like a one inch 15 / 20 degree angle on it. I had to slightly bend it to clear the wheel cover 100%.
2017 Axis / 25.4: Big Foot Levelers, Aims 1200 Watt inverter, Ceramic Window Tint, Full River AGM 6V batteries, Front Hellwig Sway bar / Rear Track Arm, Safe T Plus Steering Stabilizer, PD 4655 converter, Hard Wired Surge Guard, WEboost + WiFi Ranger, LED Headlights/Driving lights, TPMS, Surge tank, Tornado flush, Viair Compressor