We're not full-timers, but my wife often works from the road - literally.
We use Verizon for cell and data services. In most parts of the country we've visited their service has been sufficient although she hasn't tried full-motion video. She uses Magic-Jack as her business-voice provider. With a laptop, cell phone, and wireless hot spot she works while I'm driving down the road.
I run the generator when she needs a boost to her laptop battery, but I plan to add an inverter in the not too distant future that will eliminate that requirement.
The only problems have been in parts of the country where cell service is poor or non-existent. Campground WiFi should generally be considered useless for any and all high-bandwidth activities so a good cell-plan is a must.