Depends on what you want to do and how long you have. I have taken that trip dozens of times and I stay away from I 95 North of SC as much as possible. If I am in a hurry, I go up I 95 to I 77 and then work my way to I 81. I really like to stay off of I 81 as much as I can, so often I take US 29 East of the Appalachian Mountains until I 64, then cut up to I 81. I’m usually stopping off in RI so I take
I 81 to I 78 to I287 and go over the Tapanzee bridge and up I 95. Depending on where in MA you are going you could cut up to I -84 and go thru Hartford to MA.
If I have time (and I usually do being retired) I start my trip up I 75 to Macon, Ga and then up US 129 working my way to Asheville, NC and the Smokey mountains and the Blue Ridge Parkway for a week of so.
Staying off I 95 saves lots of money and traffic. GPS says it’s faster, but it almost always is not. Stay away from DC, the New Jersey TP and NYC.
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