E350/E450 same engine. The Ford V10 will tow anything within the chassis weight rating. How well it will perform depends on where and how you drive it. And what you expect from it. Ours did well in TN last year, the mountains made it work but we had no issues with them. Expect the stock transmission to down shift a lot and the revs to get pretty high but the Triton loves to wind and the computer won't let it hurt itself. The 5 star is supposed to help this but I haven't tried one.
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