Conclusion
After reading all your comments, emailing 3 manufacturers of programming devices, and speaking with The Speedo Shop in Santee, I have concluded that the computer in the 2019 E450 must be reprogrammed to make the proper comprehensive adjustments for the larger tires. Unfortunately due to the newness of this vehicle, there are no devices that can do this other than the Ford dealer which is prohibited from doing it. In time there should be aftermarket devices available. The tire size increase is 8.2% and I was advised that a change over 10% can cause issues but that 8.2% should be manageable.
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