I towed a 16.5k 5th wheel with my dually GMC which load wise would be comparable with the E350-450 class Cs, if willing to spend the extra $$ on GY tires buy the Michelins instead, from my experience you'll get near twice the mileage from the Michelins for little to no difference in price.
I have a couple friends with Ram trucks that the Nexen tires were from the factory & 30k was about max for mileage.
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Fulltimed 10+ years
Sold '13 Thor Redwood 36 FB
Traded '13 GMC Denali DRW D/A
Replacement undetermined
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