A significant number of larger (longer wheelbase) Class C tire failures seems to come from outside passenger-side rear tire. While load and pressure may play a part, I would bet that driving onto or off curves also plays a part. That’s got to stress tires significantly.
Not calling anyone out, and will admit on doing it a few times myself on longer rental motorhomes when making a sharp right turn into or out of a parking lot. Turning radius on stretched E-Series can get pretty long.
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