Some E350/E450 have handling issues, some do not, the following may explain the difference:
Ford ships all E350/E450 cut aways with identical fixed, non adjustable
caster/camber sleeves, "one size fits all". You can recognize these sleeves because they are keyed and cannot be rotated. They are marked "F8UA-AA 0+.25" on the passenger side and "E97A-CA +0-0" on the drivers side.
The RV builder almost never changes the Ford sleeves, as a result:
If the final RV build is nose down one degree then the runtime caster will be about +3.5 degrees. These units can have a real wandering problem.
If the final RV build is nose level then the runtime caster will be about +4.5 degrees. These units are probably indifferent.
If the final RV build is nose up one degree then the runtime caster will be about +5.5 degrees. These units are probably just fine.
So, some RVs have a problem with wandering at highway speeds and some do not have a problem.
Note that all three zones mentioned above are within the broad Ford caster specification.
As a result it is easy to get short changed by the "tweak the toe and we are good to go" alignment.
Discuss your symptoms up front, do not expect a normal alignment will address your handling problem.
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