I have a 2018 Chateau on the E450 chassis with the same V-10 engine. After the initial break-in period I have used full-synthetic with a Ford Motorcraft filter. Even with full synthetic I change it about every 7500 miles. Mine is a big 32 ft. RV, so it's heavy, and I often tow a car behind it, so it works hard, especially if there are any hills. The oil loses its amber color pretty quickly, and at 7500 miles definitely looks like it's ready to be changed.
I do my own oil changes. This is a very easy vehicle for a DIY oil change. The oil drain plug and filter are easily accessible, and you don't even have to jack up the vehicle. I also grease the steering linkages while I'm at it -- there are 4 grease fittings up there.
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