They do it all the time with heavy trucks, look at these:
Showhauler Motorhome Conversions
Put a nice 5th wheel on one of those and now you're talking (of course you're also looking at multiples of six figures for prices). Granted some of those showhauler's are longer than 22'--a lot longer! LOL
But basically what Chance is talking about is a "sleeper cab" kind of arrangement.
We've seen several people with higher end 5th wheels pull them with a larger truck tractor with a sleeper cab. (Some of the truly nuts arrangements put a smart car on the truck just ahead of the 5th wheel.)
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