Sounds to me like “bad gas”
Or
Unsealed gas cap causing a rare mis-fire
I have experienced similar check engine light symptoms on my E450 V-10 when it had abt 12k miles on the clock. Then again at 15k.
Both times at the next stop I removed gas cap & re-tightened.
Both times the check engine light eventually went off after several cycles.
If yours continues to cause problems you probably have no choice but to take to a Ford chassis service repair (dealer or independent)
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'17 Vegas 24.1
Fallbrook, CA
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