Besides what part of Ohio.... where do you want to end up in Florida? That will help us giving you options.
If you are heading to the Pan Handle, you could consider going through Birmingham.
If you are going to the east coast, you could pick up 26 off 81 and go through Columbia and pick up 95.
I live in Cape Coral but travel to western PA often to see family. I take 75 up to Ocala and then pick up 301 over to 10 and then over to 95 and cut over on 26 towards Columbia and then head north.
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