A bit of 'it depends'... are you using the blocks to support the full weight? or are they being used with jacks just to keep something between wheels and ground?
If the tires will be bearing the full weight (no jacks), then I would choose to block both wheels - there are dual tires there to increase the weight capacity, and would think you would likely be over the single tire capacity in a normally loaded rig... May also depend how long you will be in that position.
If using jacks that will be bearing the bulk of the weight - and blocks just so the rear wheels aren't 'off the ground' - then I think a single wheel is fine... As soon as the jack starts to lift the suspension, weight is taken off the tires - and I would expect blocking a single wheel to be more than enough.
Had a DP with dualies and tag axle pull in here - and decide to park 'nose in' to face their relatives on the next site... Changed from needing significant jack height on front to the rear - more than enough to lift the wheels... He blocked the outer wheel of the pair on each side with multiple 2x10's and left the tag hanging. The bulk of the weight is clearly on the jacks. So far hasn't gone anywhere...
Reminding me I need to replace my spare cut 2x10's - he didn't have enough.. lol