Hi, it appears the link I provided originally connects to the website....but they have blocked the particular diagram it seems.....and I am not sure which diagram it was either. You could try generically connecting to that website and do a search of various diagrams on it, or find your print out of what I originally sent. Not sure if this link will work or be of any value.
circuitswiring.com/2016 e450 fuse box - Google Search
After re-reading posts you say if you prime the engine it will start, so electrics are good (probably not crank sensor then or PCM would block spark and fuel I "think"). Fuel problem; bad pump; plugged filter. Can you hear the pump running in the tank? Prove the fuel rails have pressure etc.