We have been there many times and many ways. We love going through the Mountains. We like 65 to Indy, 70 over to Dayton, 35 to Charleston,WV. which is half way for us. $7.50 in tolls on 77 to Winston Salem, from there; depends on if your going North Myrtle or South. We usually stay near Surfside. My favorite place on earth. Enjoy!!