Pete, as far as I know (read), F-53 and E-Series motorhome chassis engines will not have stop-start, and since they are naturally aspirated, there’s no turbo to have turbo lag.
If you want turbo lag and stop-start in combination with 10-speed auto (lighter-duty version though), the smaller Transit chassis should offer both. I personally hate stop-start and prefer larger naturally-aspirated engines over smaller ones with turbos.
The real benefit of 10-speed for gas engine in my opinion when installed in large and heavy motorhomes is due to it rotating about twice as fast as diesel to make same or greater power (depending on engine model about 4,000 vs 2,000 RPMs), which means climbing steep grades in lower gears (like 3rd on a 6-speed transmission) when in 40~45 MPH range.
If we look at Ford data for 6-speed below, gear spacing is much wider between 3rd and 2nd, or 3rd and 4th, than it is between the higher gears a PowerStroke diesel will be using. That puts the gas engine at a significant disadvantage when climbing in that 40~45 MPH speed range.
However, gear spacing data for the new 10-speed shows much closer steps even in lower range, so gas engine will be able to operate in efficient RPM range much more of the time. For same conditions, it’ll be in 5th gear instead of 3rd (both same ratio), so an upshift or downshift will be more possible without redlining or bogging down the engine.
I think the new 10-speed will help diesel engine also, but not as much as the new gas engine.